• The ubiquitin like UbL proteins contain

  2020-08-04

  

  The ubiquitin like (UbL) proteins contain an integrated ubiquitin domain, but cannot themselves be conjugated to other proteins. The ubiquitin domain containing 2 (UBTD2) protein, also termed dendritic cell-derived ubiquitin (ub)-like protein (DC-UbP), is a short UbL protein that is localized to mit

• The present study demonstrates that E coli

  2020-08-04

  

  The present study demonstrates that E. coli and Taq Pol I DNA polymerases will also facilitate DNA end-joining activity in the absence of DNA synthesis by enhancing the complementary end-joining activity of E. coli DNA ligase when the polymerases are present at sub-stoichiometric concentrations rela

• DHFR deficient Chinese hamster ovary

  2020-08-04

  

  DHFR-deficient Chinese hamster ovary (CHO DHFR−) NAD+ are one of the most popular mammalian expression system for inducible amplification of transgene. Target gene is generally subcloned into vectors containing the dihydrofolate reductase (DHFR) gene which serves as the selective marker gene in CHO

• Cyclin dependent kinases CDKs are serine threonine kinase

  2020-08-03

  

  Cyclin-dependent kinases (CDKs) are serine/threonine kinase proteins comprising of 20 members that fall under protein kinases family. These enzymes play a crucial role in cell division, transcription and post-transcriptional modification [7]. For example, the formation of an active complex composed

• The enzyme cyclooxygenase COX or prostaglandin endoperoxide

  2020-08-03

  

  The enzyme cyclooxygenase (COX) or prostaglandin endoperoxide H synthase (PGHS) is the key enzyme in the conversion of arachidonic pramiracetam (AA) into prostaglandins (PGs) [1]. In 1991, researchers found that there were two isoforms of this enzyme called COX-1 and COX-2 with independent genes an

• The TPI pyrogenic black carbon

  2020-08-03

  

  The TPI pyrogenic black carbon (TPI-BC) is made of sp2-ordered carbon nanocrystallites with lateral dimensions of La∼3–8nm (Jorio et al., 2012, Ribeiro-Soares et al., 2013). Despite a structural complexity, the TPI-BC dimensionality (La) has been investigated as a critical parameter defining the sta

• Data from immunohistochemical detection of CIC revealed that

  2020-08-03

  

  Data from immunohistochemical detection of CIC-3 revealed that the immunostaining of CIC-3 can be present both in hepatocarcinoma and its matched normal controls though; CIC-3 was, on the whole, significantly elevated in hepatocarcinoma relative to its paired normal control. In consideration of the

• EMI regulates the coupling of

  2020-08-03

  

  EMI1 regulates the coupling of mitosis and DNA replication [81]. Briefly, after Gardiquimod divide, APC/CCDH1 activity must be restrained. Although this is ultimately achieved by CDH1 phosphorylation, the required CDK activity is too low in G1 due to APC/CCDH1-dependent degradation of cyclins. Thus

• br Expression data suggest involvement of additional TRIMs

  2020-08-03

  

  Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR

• br Abbreviations br Acknowledgements br Introduction Dopamin

  2020-08-03

  

  Abbreviations Acknowledgements Introduction Dopamine β-hydroxylase (DbH) is the enzyme catalysing the conversion of dopamine to norepinephrine, two important neurotransmitters involved in the central nervous system [1]. This enzyme has been isolated from bovine chromaffin granules as a tetr

• monensin The inoculation of tumor cells in the facial region

  2020-08-03

  

  The inoculation of tumor monensin in the facial region of rats also increases spontaneous facial grooming behavior, which is suggestive of spontaneous nociception in rodents (Akiyama, Carstens, & Carstens, 2010; Hidaka et al., 2011; Kopruszinski et al., 2018; Ono et al., 2009; Sago et al., 2012; Spr

• br Neglected tropical diseases The term NTD was

  2020-07-31

  

  Neglected tropical diseases The term NTD was coined by WHO to designate 18 conditions predominantly caused by parasites that mainly occur in developing countries. Altogether, these diseases affect approximately one billion people, particularly in Latin America, Asia and Africa (Molyneux, Savioli,

• It is important to note that CRF may be

  2020-07-31

  

  It is important to note that CRF1 may be activated during acute stress and early phases of anxiety disorders (Coric et al., 2010, Ising et al., 2007), as well the administration of Astressin 2B into the lateral septum did not have an effect on anxiety-like behavior in low-stress conditions but had a

• miRNAs are known to regulate the autophagy related

  2020-07-31

  

  miRNAs are known to regulate the autophagy-related genes and their activities. Also, miRNAs modulate autophagy at different stages such as autophagic induction, vesicle nucleation, vesicle elongation and completion, by targeting autophagy complexes via different miRNAs [[56], [57], [58]]. Recently,

• Ryuvidine Another way that cadherin switching can

  2020-07-31

  

  Another way that cadherin switching can affect cell behavior is by regulating Rho GTPases. E-cadherin-mediated cell-cell contacts rapidly activate Rac1 and Cdc42 and decrease RhoA activity [55,56]. Homophilic interactions of E-cadherin molecules results in the recruitment of Rac1 to the adhesion sit

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