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It is known that cigarette smoke increases
2020-03-02
It is known that cigarette smoke increases the oxidative burden in the lungs of mice with emphysema, which leads to oxidative stress [[34], [35], [36]]. However, in addition to cigarette smoke, studies have shown that endogenous oxidative stress is associated with proteolytic trans-AUCB mg in sever
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br GRAIL family Gene related to anergy
2020-03-02
GRAIL family Gene related to anergy in lymphocytes protein (GRAIL, encoded by Rnf128 gene) is a transmembrane RING-type E3 ligase involved in T cell anergy and tolerance, and also regulation of CCK-8 cytoskeletal organization [52]. This E3 was initially identified in CD4+ T helper cells and CD4+C
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Compounds were synthesized using a facile step
2020-03-02
Compounds were synthesized using a facile 8-step convergent synthesis ( and ). Briefly, (Boc)cyclen (compound ) was coupled using TBTU to Fmoc- or Cbz-protected amino alkyl acids (–), followed by deprotection using 20% piperidine in DMF, or H on Pd/C, respectively (–) (). Deprotected linkers were co
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Survival analysis has been widely used in medical science ec
2020-03-02
Survival analysis has been widely used in medical science, economics, finance, and social science, among others. In many studies, survival data have primary outcomes or responses that are subject to censoring. The Cox model [7], [8] is the most commonly used regression model for survival data, and t
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Enhanced responses to varying concentrations of
2020-03-02
Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of ubiquitin activating enzyme and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-ind
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EPAC activation in VSMCs and ECs reverses several processes
2020-03-02
EPAC activation in VSMCs and ECs reverses several processes involved in the development of in-stent restenosis. Of particular relevance is the ability of EPAC1 to induce SOCS3 gene expression, as SOCS3 exerts multiple protective effects in both cell types, while immunohistochemical studies have show
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br Concluding Remarks Recent studies have provided unprecede
2020-03-02
Concluding Remarks Recent studies have provided unprecedented details of APC/C structure and enzymology, which explain how the activity of this massive E3 ligase is controlled, and how ubiquitylation is achieved to temporally regulate cell division. Although one pervasive question has been why th
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Saito et al reported that d http www apexbt
2020-03-02
Saito et al. reported that diabetic bone has lower lysyl oxidase-derived enzymatic cross-links in collagen compared to non-diabetic bone, based on studies performed in a rat model [9]. Lysyl oxidase plays a pivotal role in bone development and function, as revealed in classical studies [10], [11]. L
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Introduction Quassinoids are natural products formed through
2020-03-02
Introduction Quassinoids are natural products formed through the oxidative degradation of triterpene derivatives with anti-inflammatory, antimicrobial, antineoplastic, and antiplasmodial effects (Chakraborty and Pal, 2013; Houël et al., 2013). They are characteristic ingredients of the family Simar
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GKT137831 Nuclear export mediated by CRM
2020-03-02
Nuclear export mediated by CRM1 is initiated by an interaction between RanGTP and the HEAT9 loop of CRM1, triggering a conformational change in the NES binding site that permits NES–cargo protein binding (Dong et al., 2009, Fung and Chook, 2014). Our docking simulation results predicted that DP2392-
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In rats exposed to day of nicotine
2020-03-02
In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w
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br Introduction Alzheimer s disease AD
2020-02-28
Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the DIDS nerves cells, or neurons, resulting in loss of memory, impairment of thinking and
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br Orthotopic liver transplantation OLT is the
2020-02-28
Orthotopic liver transplantation (OLT) is the only curative therapy available for patients with end-stage liver disease. The surgical procedure of liver transplantation inherently involves cold ischemia during graft preservation , followed by reperfusion of the transplanted graft which results in
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JIB-04 receptor Studies have shown that the cultivation of B
2020-02-28
Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem JIB-04 receptor (Liu et al., 2010, Liu et al., 2014a, Zia
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Our results indicate a deregulation of DNA
2020-02-28
Our results indicate a deregulation of DNA methylation machinery during seed development in apomixis. Since DRM2 is targeted loci through an RNA-directed DNA methylation (RdDM) pathway involving 24-nt siRNAs (Stroud et al., 2014, Law and Jacobsen, 2010) and differentially expressed between apomict a
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