• It is well known that Doxorubicin induced cardiotoxicity occ

  2020-03-05

  

  It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot

• The need for dedicated DAPT updates is well justified by

  2020-03-05

  

  The need for dedicated DAPT updates is well justified by the large amount of data and new information generated in the field over the past few years. As expected, the ACC/AHA and ESC updates contain large areas of overlap as well as some differences. Differences were largely explained by the differe

• br Experimental Procedures br Author Contributions br Acknow

  2020-03-05

  

  Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s

• Nimodipine is an L type calcium channel

  2020-03-05

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• These findings further extend our knowledge

  2020-03-05

  

  These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a

• br Acknowledgments This study was supported by grants

  2020-03-04

  

  Acknowledgments This study was supported by grants from the Spanish Ministry of Economy and CompetitivenessPI10/00387, PI12/01087, PI12/01703, IPT-2011-0817-010000, and RIC Red de Investigación Cardiovascular (RIC)RD12/0042/0055. RIC is an initiative of Instituto de Salud Carlos III (ISCIII), Spa

• Hinokitiol has versatile abilities as anticancer

  2020-03-04

  

  Hinokitiol has versatile abilities as anticancer, antimicrobial and molecule transport agents and appears to have no developmental toxicity or carcinogenic effects (Imai et al., 2006b). For anticancer activities, it causes apoptosis and Fluconazole arrest in many different types of cancers, such as

• MicroRNA miRNA is a class of highly conserved non

  2020-03-04

  

  MicroRNA (miRNA) is a class of highly conserved, non-coding small molecules containing 19–25 nucleotides. miRNAs are involved in the regulation of genes associated with cancer development and progression and therefore can act as oncogenes, by contributing to tumor formation,17, 18 or as tumor suppre

• To explore the mechanism behind differential activation kine

  2020-03-04

  

  To explore the mechanism behind differential activation kinetics, Marcott et al. (2018) manipulate local dopamine dynamics. They show that differences in dopamine concentrations are not responsible for different D2R activation kinetics, since D2-IPSCs reach similar amplitudes at different rates in

• Our study showed that parental morphine exposure in the adul

  2020-03-04

  

  Our study showed that parental morphine exposure in the adulthood is associated with an increased tendency toward morphine consumption in F1 but not F2 male offspring. Thus, it seems that trans-generational effects of parental morphine consumption disappear in the second generation. In support of ou

• The DNA damage response DDR

  2020-03-04

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as apelin receptor regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been r

• In conclusion over expression of Stokesia epoxygenase

  2020-03-04

  

  In conclusion, over-expression of Stokesia epoxygenase (SlEPX) in soybean seeds led to some unusual seed phenotypes. These effects can be overcome by coexpression of Vernonia DGATs (VgDGAT1 & 2). The DGATs can specifically transfer vernolic AG-126 into TAG, largely reducing vernolic acid levels in m

• In order to assess quantitatively the

  2020-03-04

  

  In order to assess quantitatively the contribution of the ung, dug and dut 17 alpha hydroxylase to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The me

• br Materials and methods br Results br Discussion Although n

  2020-03-04

  

  Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the NG,NG-dimethyl-L-Arginine hydrochloride following HI is not synchronized enough to yi

• An important strength of our

  2020-03-04

  

  An important strength of our study is the use of an elastic net regression model to select the variable and construct the model, which performed ideally in terms of both predictive accuracy and sparsity for the high-dimensional datasets [16]. As a result, the apparent predictive effect of multiple c

8984 records 405/599 page Previous Next First page 上5页 401402403404405 下5页 Last page