• In primary diagnosis IKZF status was

  2019-05-07

  

  In primary diagnosis IKZF1 status was not taken into account for risk group stratification. According to protocol ALL-MB-2002 regulations, risk was underestimated and patient was assigned to the SRG. Prognostic value of IKZF1 alterations in ALL, especially BCR-ABL1 negative ALL, is still debated [19

• Abstract Background Substantial progress has been

  2019-05-07

  

  Abstract Background Substantial progress has been made in reducing the incidence and prevalence of malaria. In 2016, 111 countries have eliminated malaria and another 35 countries, are making progress toward elimination of the disease. However, little is known about how much governments and donors

• Bennet and colleagues also make an important

  2019-05-07

  

  Bennet and colleagues also make an important addition to the literature on the Affordable Medicines Facility—malaria (AMFm) intervention, since a comparison of ACT treatment coverage for countries that had the AMFm intervention is made with those for countries that did not have the AMFm intervention

• br Heart rate turbulence HRT

  2019-05-07

  

  Heart rate turbulence (HRT) HRT was introduced by Schidmt in 1999 [11]. It refers to the physiological phenomenon in response to a premature beat. After a ventricular premature contraction (VPC) and a compensatory pause, there is an increase in blood pressure because of the prolonged filling. Ref

• br Conflicts of interest br Funding This study

  2019-05-07

  

  Conflicts of interest Funding This study was supported by grants from the Ministry of Science and Technology, Taiwan (MOST-103-2314-B-002-090). Introduction Ancient schwannoma is an uncommon variant of schwannoma, which arises from the nerve sheath Schwann cells, with a typically long cour

• br Discussion It is generally known that primary

  2019-05-07

  

  Discussion It is generally known that primary CNS melanomas are rare and difficult to diagnose prior to biopsy. According to tumor melanin content, four subtypes of malignant intracranial melanoma have been proposed, associated with different MRI image presentations. These subtypes are: 1) melano

• In this case report we

  2019-05-07

  

  In this case report, we described a rare case of tumor lysis syndrome associated with the FOLFOX regimen and further stress the importance of additional prophylaxis for the huge tumor burden. Our patient\'s hyperammonemia may be due to cardiogenic shock, post cardio-pulmonary-cerebral resuscitation

• br How do you manage patients on intravenous bone targeted

  2019-05-07

  

  How do you manage patients on intravenous bone-targeted agents who require dental work? For patients who are on IV bisphosphonate therapy and require dento-alveolar procedures there is a suggestion that prophylactic antibiotic use around the procedure may be helpful in reducing ONJ risk [45,49].

• Further complicating matters is that although

  2019-05-07

  

  Further complicating matters is that although menopause can increase serum BTMs, other normal physiological conditions, certain disease states, and drugs are also associated with elevated BTM concentrations [81–83]. Low body-mass index (BMI) is a risk factor for low bone density [84] and evidence ha

• The majority of breast malignancies are hormone

  2019-05-07

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• The aim of this study was to determine the therapeutic

  2019-05-06

  

  The aim of this study was to determine the therapeutic relevance of blocking RANKL in Ewing\'s sarcoma by using OPG administered by non-viral gene transfer approaches in two models of human Ewing sarcoma in immunodeficient mice. OPG was administered using amphiphilic polymers constituted by blocks o

• Paying now rather than forever has never been as

  2019-05-06

  

  Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set

• br VIII Si atendemos a que Pablo del Prado en

  2019-05-06

  

  VIII. Si atendemos MLN4924 que Pablo del Prado en su Directorio espiritual, todavía en el año de 1650, incorporaba numerosas oraciones para la comunión espiritual indígena, junto a recomendaciones sobre la exclusión de la efectiva, no parece probable que se alcanzara nunca una normalización del h

• MRS 2578 br INTRODUCCI N br Qu hacer con las derrotas

  2019-05-06

  

  INTRODUCCIÓN ¿Qué hacer con las derrotas políticas? ¿Qué hacer frente MRS 2578 ellas? ¿Cómo procesarlas y transfigurarlas en una escuela de conocimiento? Sin duda, estos interrogantes recorren como un fantasma toda tradición de pensamiento y transformación que se precie de ser crítica. Casi si

• Second political regime does very little to explain

  2019-05-06

  

  Second, political regime does very little to explain differences between countries. Rwanda, Congo (Brazzaville), and Tanzania have very similar child mortality rates (between 40 and 60 deaths per 1000 livebirths in 2014) to South Africa, Botswana, and Namibia despite the former countries being consi

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