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In conclusion we expect that this VP
2018-10-20

In conclusion, we expect that this VP64dCas9-BFPVP64 platform, which is significantly more potent than previous versions, will encourage the adoption of CRISRP/Cas9-based TF technology to achieve multiplexed gene activation for reprogramming as well as nonreprogramming applications in basic science,
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Our results suggest several open questions that will require
2018-10-20

Our results suggest several open questions that will require further investigation. Although evidence suggests that eradication of cancer stem order AMG 925 appears to be beneficial for curing cancers, recent studies also suggest that noncancer stem cells acquire a cancer stem cell phenotype when c
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In summary we demonstrate that GRM functions
2018-10-20

In summary, we demonstrate that GRM7 functions as a modulator of neurogenesis. We identify CREB, YAP, and CYCLIND1 as the downstream targets of GRM7. The phosphorylation of CREB at Ser133 and the expression of YAP and CyclinD1 are modulated by GRM7, thereby regulating neurogenesis. Future behavioral
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The Xenopus homolog of Bucky ball is
2018-10-20

The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te
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br Material and methods br Results br Discussion
2018-10-20

Material and methods Results Discussion The role of CD146 in Sitagliptin phosphate monohydrate of the adipose niche is not precisely understood. Studies analyzing its expression in human ASCs are inconsistent (Frazier et al., 2016; Mitchell et al., 2006; Pachón-Peña et al., 2011; Varma et
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RNA splicing occurs in spliceosomes
2018-10-20

RNA splicing occurs in spliceosomes, which is a complex consisting of RNA and proteins, including five small nuclear RNAs (snRNAs) (U1, U2, U4, U5, and U6 snRNA), hundreds of auxiliary protein factors, and small nuclear ribonucleoproteins (snRNPs) (Reed et al., 1988). The RNA splicing process is cat
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br Experimental Procedures br Author Contributions br Acknow
2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri
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buy Avasimibe br Experimental Procedures br Author Contribut
2018-10-20

Experimental Procedures Author Contributions Acknowledgments We are grateful to Y. Okada (Aichi Medical University) and T. Matsumoto (Ajinomoto) for technical assistance, helpful advice, and discussions; T. Abe (Keio University) for statistical analysis; and all members of the H.O. laborato
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SOX is an essential factor in the maintenance
2018-10-20

SOX2 is an essential factor in the maintenance of both human and murine pluripotency; however, it is upregulated, along with other pluripotency factors, in murine PGCs but not hPGCs. In this study we have clarified the mechanism of its repression in the hPGC-derived TCam-2 SEM b-AP15 Supplier and s
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br Experimental Procedures br Author Contributions br Acknow
2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Abhishek Sinha, Chandan Kadur, James Ankrum, and Mamta Jain for helpful and enlightening discussions. Funding supported by the Indo-US Science and Technology Forum (IUSSTF) to J.M.K. and M.S.I.; JNCASR grant to M.S.I.; an
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br Experimental Procedures br Author Contributions br Acknow
2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The onset of puberty is regulated by a small population of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, which secrete GnRH decapeptide to the hypophyseal portal system. Unlike other neuroendocrine ce
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br Results br Discussion Given
2018-10-20

Results Discussion Given the physiological similarities of cardiomyocytes between zebrafish and human (Brette et al., 2008; Nemtsas et al., 2010), the zebrafish has emerged as an outstanding system for studying cardiac development and regeneration, performing cardiac-associated phenotypic scre
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The correct deposition of m C
2018-10-20

The correct deposition of m5C into RNAs is essential for normal development. Loss-of-function mutations in the NSUN2 gene in both mouse and human cause growth retardation and neurodevelopmental deficits including microcephaly, as well as defects in cognition and motor function (Blanco and Frye, 2014
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2018-07-29
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