RNA splicing occurs in spliceosomes

2018-10-20

RNA splicing occurs in spliceosomes, which is a complex consisting of RNA and proteins, including five small nuclear RNAs (snRNAs) (U1, U2, U4, U5, and U6 snRNA), hundreds of auxiliary protein factors, and small nuclear ribonucleoproteins (snRNPs) (Reed et al., 1988). The RNA splicing process is cat

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri

buy Avasimibe br Experimental Procedures br Author Contribut

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We are grateful to Y. Okada (Aichi Medical University) and T. Matsumoto (Ajinomoto) for technical assistance, helpful advice, and discussions; T. Abe (Keio University) for statistical analysis; and all members of the H.O. laborato

SOX is an essential factor in the maintenance

2018-10-20

SOX2 is an essential factor in the maintenance of both human and murine pluripotency; however, it is upregulated, along with other pluripotency factors, in murine PGCs but not hPGCs. In this study we have clarified the mechanism of its repression in the hPGC-derived TCam-2 SEM b-AP15 Supplier and s

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Abhishek Sinha, Chandan Kadur, James Ankrum, and Mamta Jain for helpful and enlightening discussions. Funding supported by the Indo-US Science and Technology Forum (IUSSTF) to J.M.K. and M.S.I.; JNCASR grant to M.S.I.; an

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The onset of puberty is regulated by a small population of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, which secrete GnRH decapeptide to the hypophyseal portal system. Unlike other neuroendocrine ce

br Results br Discussion Given

2018-10-20

Results Discussion Given the physiological similarities of cardiomyocytes between zebrafish and human (Brette et al., 2008; Nemtsas et al., 2010), the zebrafish has emerged as an outstanding system for studying cardiac development and regeneration, performing cardiac-associated phenotypic scre

The correct deposition of m C

2018-10-20

The correct deposition of m5C into RNAs is essential for normal development. Loss-of-function mutations in the NSUN2 gene in both mouse and human cause growth retardation and neurodevelopmental deficits including microcephaly, as well as defects in cognition and motor function (Blanco and Frye, 2014

Hello world!

2018-07-29