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ap-1 Fig demonstrates placental amino acid transporter
2021-10-11
Fig. 7 demonstrates placental amino ap-1 transporter protein concentrations. While no change in the placental SNAT2 is effected in response to a high-fat diet in wt, a trend toward a reduction was seen in glut3 mice in response to a high-fat vs. chow diet (Fig. 7A and B). A high-fat diet did not ch
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Despite the potential promise of both
2021-10-11
Despite the potential promise of both of these peptides, such compounds are still susceptible to efficient renal filtration (Emmanouel et al., 1978, Holst, 1991, Deacon et al., 1996). However, numerous studies have demonstrated that fatty 1478 dervatisation of related regulatory peptides results in
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Mongolian gerbils Meriones unguiculatus a
2021-10-11
Mongolian gerbils (Meriones unguiculatus), a social rodent species, are widely distributed in the typical steppe, desert steppe and desert habitats of northern China, Mongolia, and Trans-Baikal region of Russia. In wild, the recorded maximum lifespan (apparent longevity) was 29.5 months for female M
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br Acknowledgements Research was funded
2021-10-09
Acknowledgements Research was funded by the Natural Sciences and Engineering Council of Canada (NSERC) (Grant #210290) SGF. The funding body played no role in the design or execution of the study. The authors declare no conflict of interest. Introduction HBO2 therapy is the use of 100% oxygen
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Considering the fact that NADPH oxidase is the main
2021-10-09
Considering the fact that NADPH oxidase is the main source for paraquat and maneb-induced oxidative stress, we hypothesized that NADPH oxidase activation might contribute to dopaminergic neurodegeneration induced by paraquat and maneb through ferroptosis. To test our hypothesis, we investigated the
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br Materials and methods br
2021-10-09
Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa Moniliformin sodium salt to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in
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In order to establish proper folding
2021-10-09
In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both MMP-2/MMP-9 Inhibitor I contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), wh
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At days and hours after MI the protein expressions of
2021-10-09
At 21 days and 24 hours after MI, the protein expressions of active JNK1 (P Probenecid of p38 was down-regulated only at 21 days after MI (P Discussion This study demonstrates the role of GSTP1 in HF by inhibiting the TRAF2-induced MAPK activation and the potent inhibitory effect of GSTP1 on TNF
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The ketone body receptor HCA is most
2021-10-09
The ketone body receptor HCA2 is most likely not active under normal conditions, since local levels and plasma levels of ketone bodies such as β-HB are too low to activate the receptor. However, overnight fasting or prolonged starvation results in plasma levels of the ketone body in the millimolar r
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br Gastrointestinal peptides and intestinal health Gastroint
2021-10-09
Gastrointestinal peptides and intestinal health Gastrointestinal peptides are intimately involved in the regulation of feeding behaviors, energy metabolism and bodyweight 36, 37, 38, 39, 40, 41. GPR120 has been demonstrated to induce secretion of two such peptides: GLP-1 and cholecystokinin (CCK)
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Introduction Substantial body of evidence
2021-10-09
Introduction Substantial body of evidence supports the notion that GABA, the dominant inhibitory neurotransmitter in the hypothalamus of mammals, affects GnRH release by two classes of membrane receptors: GABAA (GABAAR) [1] and GABAB (GABAB R) [2]. Studies in rodents and sheep have documented that
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g-quadruplex br Results and discussion br
2021-10-09
Results and discussion Conclusion In this study the first binding assays based on a nonlabelled reporter ligand addressing GlyT1 are described. Following the concept of MS Binding Assays recently introduced in our group, binding of the well-known GlyT1 inhibitor Org24598 employed as reporter
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Studies dealing with the effects of
2021-10-09
Studies dealing with the effects of ischemia on EAATs have been previously reported, but some discrepancies in literature appear between them probably as a consequence of the different models, species, time of reperfusion after ischemia and age of the animals. Thus, in human, brdu stroke-dependent
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The ester moiety is a promising structural
2021-10-09
The ester moiety is a promising structural motif at the C-3 position for the development of drug-like molecules. However, the labile C-3 ester bond impels these derivate to be susceptible to plasmatic degradation by esterases and this is natural steroidal metabolic process [39,40]. Hence, the isoste
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The bFGF induced upregulation of both GR and
2021-10-09
The bFGF-induced upregulation of both GR and MR levels observed in our study raises a question regarding whether the simultaneous augmentation of the two receptors has a physiological and/or medical significance. It has been suggested that MR stimulates intracellular signaling pathways to minimize s
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